Topic: spatial bias

The ability to modify established behavior in novel situations is essential. We designed a behavioral paradigm to test whether novelty exposure facilitates behavioral flexibility. Male mice ran free choice sessions in which they can freely choose an arm of a T-maze to get a reward for 3 days. As a result, mice developed an efficient strategy to simply choose one particular side 90 % of the time (arm bias). The following day, mice were exposed to either a novel or familiar arena and trained on a delayed-non-match-to-sample flexible choice task. Mice had to learn to overcome their established bi