Impaired spatial coding and weak hyperactivity in the medial entorhinal cortex of aged APP knock-in mice
Gustavo Rodriguez, Eva Rothenberg, Oliver Shetler, Andrew Aoun, Lorenzo Posani, Thomas Tedesco, Stefano Fusi, Abid Hussaini · FENS Forum 2024
Pathological amyloid beta (Aβ) accumulation in the brain has been associated with poor cognitive performance and aberrant neuronal activity in preclinical mouse models of Alzheimer’s disease (AD). Here, we assessed the impact of advanced Aβ pathology on spatial information processing in the medial entorhinal cortex (MEC) of 18-month APP NL-G-F knock-in mice as they explored contextually novel and familiar open field arenas in a two-day, four-session recording paradigm. Using in vivo electrophysiology, we tracked single-units across all sessions and found that MEC single-unit spatial informatio
ePoster · Neuroscience