Hippocampal-thalamo-cortical coupling in spatial learning and memory consolidation
Myriam Azzarelli, Antoine Ghestem, Vinicius Lima Cordeiro, Paul-Arno Lamarque, Maëva Ferraris, Christophe Bernard, Marco Pompili, Pascale Quilichini · FENS Forum 2024
Spatial memory consolidation is supported by the coupling of hippocampus (HPC) and medial prefrontal cortex (mPFC) activities during sleep. The thalamic nucleus reuniens (NR), reciprocally connected to the HPC and the mPFC, is thought to play a key role in this process. In order to characterize the interactions of these structures during memory consolidation, we developed a new experimental protocol. On an automated maze, animals learn a daily trajectory to a reward and are tested for performance in subsequent sleep. During this protocol, we conduct high-density recording of the HPC, NR and mP