Deciphering the role of neuronal interleukin-1 receptor in early life stress-induced social behavior deficits
Marianne Charlene Monet, Maria Smirnova, Ning Quan · FENS Forum 2024
Early life stress (ELS) has profound and enduring effects on neurodevelopment and social functioning, contributing to the risk of neurodevelopmental disorders. The interleukin-1 receptor (IL-1R1) in the hippocampus plays a pivotal role in mediating the impact of stress on social behavior. However, the involvement of neuronal IL-1R1 (nIL-1R1) in ELS-induced social deficits remains poorly understood. This study aims to address this gap by utilizing a maternal separation (MS) paradigm and innovative cell-type-specific IL-1R1-expressing mouse lines to elucidate the role of nIL-1R1 in MS-induced lo
ePoster · Neuroscience