Topic: spatial rule-switching

The medial prefrontal cortex (mPFC) has a broad role in cognitive flexibility and executive function, as well as long-term memory consolidation. These distinct functions are reconciled by the mPFC’s role in context-dependent decision making, which requires the evaluation and selection of representations that are relevant for a particular goal.The hippocampus and mPFC interact via direct and indirect pathways. Coordinated activity between these regions occurs both during hippocampal theta and sharp-wave ripples (SWRs) and is correlated with performance during tasks that rely on spatial informat