Structure of spontaneous activity in mouse visual cortex
Ali Haydaroglu, Valentin Schmutz, Michael Krumin, Charu Reddy, Samuel Dodgson, Lanxin Xu, David Meyer, Jingkun Guo, Andrew Landau, Maxwell Shinn, Sophie Skriabine, Alipasha Vaziri, Kenneth Harris, Matteo Carandini · COSYNE 2025
Introduction: Spontaneous activity in visual cortex is high-dimensional and state-dependent, yet its organizing principles are unclear (Stringer et al. Science 2019; Berkes et al. Science 2011). We combine large-scale imaging, modelling, and theory to ask: 1. Does spontaneous activity share the structure of evoked activity? 2. Is spontaneous activity organized spatially? Methods: We constructed a modified Light Beads Microscope (Demas et al. Nature Methods 2021) to image Ca2+ transients in excitatory neurons from large volumes. We developed an open-source, GPU-accelerated volumetric cell extra
ePoster · Neuroscience