ePoster · Neuroscience
State modulation in spatial networks with three interneuron subtypes
Chengcheng Huang, Madeline Edwards, Jonathan Rubin · COSYNE 2025
Neuronal responses to sensory stimuli are strongly modulated by an animal’s brain state. Three distinct subtypes of inhibitory interneurons, parvalbumin (PV), somatostatin (SOM), and vasoactive intestinal peptide (VIP) expressing cells, have been identified as key players in flexibly modulating sensory responses [1]. The three interneuron populations have specialized local microcircuit motifs and are targeted differentially by neuromodulators and top-down inputs from higher-order cortical areas. However, the distinct contribution of each interneuron subtype to modulating a cortical network’s d