A bistable inhibitory optoGPCR for multiplexed optogenetic control of neural circuits
Jonas Wietek, Adrianna Nozownik, Mauro Pulin, Inbar Saraf-Sinik, Noa Matosevich, Raajaram Gowrishankar, Asaf Gat, Daniela Malan, Bobbie J. Brown, Julien Dine, Bibi Nusreen Imambocus, Rivka Levy, Kathrin Sauter, Anna Litvin, Noa Regev, Suraj Subramaniam, Khalid Abrera, Dustin Summarli, Eva Madeline Goren, Gili Mizrachi, Eyal Bitton, Asaf Benjamin, Bryan A. Copits, Philipp Sasse, Benjamin R. Rost, Dietmar Schmitz, Michael R. Bruchas, Peter Soba, Meital Oren-Suissa, Yuval Nir, J. Simon Wiegert, Ofer Yizhar · FENS Forum 2024
Information is transmitted between brain regions through the release of neurotransmitters from long range projecting axons. Understanding how the activity of such long-range connections contributes to behavior requires efficient methods for reversibly manipulating their function. Chemogenetic and optogenetic tools, acting through endogenous G-protein coupled receptor (GPCRs) pathways, can be used to modulate synaptic transmission, but existing tools are limited in sensitivity, spatiotemporal precision, or spectral multiplexing capabilities. Here we systematically evaluated multiple bistable op
ePoster · Neuroscience