Topic: spectrin tetramers

The advent of superresolution microscopy uncovered the presence of the membrane-associated periodic skeleton (MPS), a part of the neuronal cytoskeleton that is organized in a periodic localization pattern. Central to this structure are spectrin tetramers, which localize rings of actin filaments at an average distance of 190 nm. The MPS is particularly pronounced in the axon, where it appears able to recruit ion channels and signaling platforms into similar periodic localization patterns, suggesting the MPS plays a key role in orchestrating neuronal signaling. Despite this, precise quantificati