Topic: spike amplitude

It is well-established that neurodegenerative diseases lead to structural and functional reconfigurations in neural networks. However, it is less clear how altered network dynamics contribute to increased vulnerability of specific neuronal populations to disease onset and spread. Here, we aimed to identify how ALS pathology affects the structural and functional dynamics of motor neuron networks, and the underlying biological pathways that contribute to cause such dysfunction. Multielectrode arrays (MEAs) enable longitudinal assessment of electrophysiological activity in vitro, thus facilitatin