Topic: spike sequences

To navigate accurately, the brain requires an internal map of the external spatial world. The entorhinal cortex (EC) is thought to play an important role in the generation of this internal map, as it contains grid cells that fire periodically in space. However, grid cells are also active at rest, replaying grid cell spike sequences that reflect spatial sequences observed during mobility [1,2,3]. Replay events are thought to play an important role in memory and planning. Little is known, however, on the spatial structure of entorhinal replay, limiting our understanding of how grid cells partici