Topic: spike timing-dependent potentiation

Episodic memory formation in the mammalian brain is steered by synaptic plasticity processes in the hippocampus. The dorsal hippocampus is instrumental for spatial learning whereas the ventral hippocampus is required for emotional functions. We studied how GABAergic inhibition regulates spike timing-dependent potentiation (t-LTP) at Schaffer collateral-CA1 synapses along the longitudinal axis of the hippocampus using acute brain slices of male C57Bl/6J mice. To this aim we used two distinct t-LTP protocols that rely on six repeats of paired pre- and postsynaptic firing within 10 seconds, resem