Therapeutic effect of extracellular vesicles derived from mesenchymal stem cells in amyotrophic lateral sclerosis
Francesca Bacchetti, Matilde Balbi, Debora Giunti, Francesca Provenzano, Benedetta Parodi, Carola Torazza, Tiziana Bonifacino, Cesare Usai, Nicole Kerlero de Rosbo, Antonio Uccelli, Giambattista Bonanno, Marco Milanese · FENS Forum 2024
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by selective death of motoneurons (MNs). Our previous results revealed that intravenous administration of mesenchymal stem cells (MSCs) improved different pathological features in SOD1G93A ALS mice. We hypothesised that the beneficial effect could be mediated by paracrine activity of extracellular vesicles (EVs) secreted by MSCs shuttling microRNAs . Subsequently, we studied in-vitro the activity of MSCs-derived EVs on spinal cord astrocytes of symptomatic SOD1G93A mice. The results demonstrated that 24h in-
ePoster · Neuroscience