Anti-nociceptive effects of non-antibiotic derivatives of demeclocycline and doxycycline against formalin-induced pain stimulation
Elaine Del-Bel, Glauce Crivelaro do Nascimento, Airam Nicole Vivanco, Laurent Ferrie, Bruno Figadere, Rita Raisman-Vozari, Patrick Michel · FENS Forum 2024
Previous tetracycline (TC) studies hinted at its analgesic potential. We explored here it in new non-antibiotic TC derivatives. Using the formalin-induced nociceptive pain model in male adult C57⁄BL6 mice, we tested the effects of DDMC (5, 10, 20 mg.kg-1) and DDOX (10, 20, 40 mg.kg-1), non-antibiotic derivatives of demeclocycline and doxycycline, respectively. A sub-chronic treatment with 5 mg.kg-1 of DDMC remarkably reduced nociceptive pain in both phases of the test, comparable to morphine (10 mg.kg-1). DDOX was also effective but intrinsically less potent than DDMC as exerting analgesic eff
ePoster · Neuroscience