Prolonged enhancement of spinal cord neuron activity by synaptic input from sensory neurons in reconstructed sensory-spinal cord network in vitro
Yuki Miyahara, Shimba Kenta, Kotani Kiyoshi, Jimbo Yasuhiko · FENS Forum 2024
While normal pain perception is necessary for increasing survival possibility of organisms, chronic pain is a great source of disability and is a serious social problem. On pain perception, dorsal root ganglion (DRG) neurons generate electrical activity by nociceptive stimuli, and transmit signals toward spinal cord. Alteration in pain processing circuit of spinal cord network can cause a type of chronic pain called nociplastic pain. Conventional studies using model animals are limited to investigate the complex mechanisms of functional changes in neural networks. In this study, we aimed to re
ePoster · Neuroscience