Spinal cord injury modulates the therapeutic capacity of transplanted cells in a model mimicking autotransplantation
Quentin Delarue, Pauline Neveu, Matthis Brodier, Amandine Robac, Axelle Blondin, Baptiste Pileyre, Pamela Lecras, Alizée Hugede, Clémence Raimond, Gaëtan Riou, Nicolas Guerout · FENS Forum 2024
Spinal cord injury (SCI) is a trauma that results in loss of function below the site of injury. Additionally, SCI induces systemic inflammation, which is in part responsible of brain dysfunction. Currently, many therapeutic approaches have been carried out. In particular, transplantation of bulbar olfactory ensheathing cells (bOECs) has shown therapeutic effects in mice and, to a lesser extent, in humans. Given these observations, we wondered about the effect of the lesion on the quality of the transplanted therapeutic material when cells are harvested after SCI. First, the effects of SCI on b
ePoster · Neuroscience