Involvement of peptidergic Edinger-Westphal nucleus in the neurobiology of migraine
Ammar Al-Omari, Balázs Gaszner, Dóra Zelena, Kinga Gecse, Gergely Berta, Tünde Biró-Sütő, Péter Szocsics, Zsófia Maglóczky, Péter Gombás, Pintér Erika, Gabriella Juhász, Viktória Kormos · FENS Forum 2024
The urocortin 1 (UCN1)-expressing neurons of the centrally projecting Edinger-Westphal nucleus (EWcp) are affected by the circadian rhythm, hormonal changes, stress and pain that are known to trigger migraine. Here we aimed at investigating the possible role of EWcp in migraine neurobiology.RNAscope in situ hybridization (ISH) combined with immunostaining was used to examine the expression of calcitonin gene-related peptide (CGRP) receptor component (Crcp) in both mouse and human EWcp and dorsal raphe nucleus (DRN). Anterograde and retrograde tracing study investigated the neuroanatomical conn
ePoster · Neuroscience