Topic: spine geometry

Long-term potentiation (LTP) can have an early phase constituting a transient increase in synaptic strength, and a late phase sustaining this increase. The synaptic tagging and capture hypothesis states that the late phase occurs if the stimulus leads to a transient ‘synaptic tag’ along with plasticity-related protein (PRP) synthesis. If both are present, the post synaptic density (PSD) remodels, giving rise to long-lasting changes in the synaptic weight. With computational modelling, we test the hypothesis that actin dynamics in interaction with spine geometry acts as a synaptic tag.Actin dyn