Resilience to changes in hippocampal excitatory synapses contribute to cognitively healthy Tg2576 mice
María de los Llanos Martínez Poyato, Carolina Aguado, Sara Badesso, José Martínez-Hernández, Alejandro Martín-Belmonte, Rocío Alfaro-Ruiz, Miriam Fernández, Ana Esther Moreno-Martínez, Mar Cuadrado-Tejedor, Ana García-Osta, Rafael Luján · FENS Forum 2024
Some individuals with Alzheimer’s disease (AD) pathology exhibit cognitive resilience, offering promising prospects for identifying new therapeutic targets.Aims: Our hypothesis centers around the contribution of resilience to changes in excitatory synapses at the structural and molecular levels, which may underlie healthy cognitive performance in aged AD animals.Methods: We used Morris Water Maze tests, ELISA, western blots, stereological methods and immunoelectron microscopy.Results: Utilizing the Morris Water Maze test, we selected resilient (asymptomatic) and cognitively impaired aged-Tg257
ePoster · Neuroscience