Unexpected contribution of striatal projection neurons co-expressing dopamine D1 and D2 receptors in balancing motor control
Pilar Martínez Olondo, Patricia Bonnavion, Christophe Varin, Ghazal Fakhfouri, Aurélie de Groote, Amandine Cornil, Ramiro Lorenzo López, Elsa Isingrini, Elisa Pozuelo, Kathleen Xu, Eleni Tzavara, Erika Vigneault, Sylvie Dumas, Alban de Kerchove d'Exaerde, Bruno Giros · FENS Forum 2024
The prevailing model of the basal ganglia motor control posits that the striatum, the input nucleus fo the basal ganglia, orchestrates the selection of voluntary actions through two circuits, the direct and the indirect pathways that oppose each other in thalamocortical activation. These circuits originate from two different populations of spiny projecting neurons (SPNs) projecting to different output structures and classically distinguished by differential expression of dopamine (DA) D1 receptor- and D2 receptor (D1-SPNs and D2-SPNs), respectively, regardless of SPNs co-expressing these two r
ePoster · Neuroscience