Modelling the stress response in SH-SY5Y-derived neurons: Disentangling the mineralocorticoid and glucocorticoid receptors
Justin Lugenbühl, Clara Snijders, Cameron Pernia, Marina Soliva Estruch, Gunter Kenis, Nikolaos Daskalakis · FENS Forum 2024
Post-traumatic stress disorder (PTSD) is a debilitating stress-related psychiatric disorder that can develop following trauma exposure in some individuals. Among others, it is characterized by a dysregulated hypothalamic – pituitary – adrenal axis, which is predominantly regulated by the glucocorticoid receptor (GR) and the mineralocorticoid receptor (MR). The neurobiological processes leading to disease remain largely unknown. In vitro models are promising tools to investigate specific neurobiological underpinnings of the stress response in the brain. Here, we investigated the suitability of
ePoster · Neuroscience