Functional impairments of striatal neurons in Huntington’s disease: Fast-spiking interneurons and their key role during the early stages of the pathology
Arianna Trucco, Paolo Spaiardi, Antonio Nicolas Castagno, Francesca Raffin, Maria Mancini, Jessica Cazzola, Giorgia Faravelli, Francesca Talpo, Gerardo Biella · FENS Forum 2024
Huntington’s disease (HD) is a severe genetic neurodegenerative disorder. Cortex, striatum, and their connectivity are mostly affected by this pathology. Numerous studies have delved into the dysfunction of striatal spiny projection neurons (SPNs) in HD; however, several questions still remain unanswered: are certain populations of striatal neurons spared by HD? Does the extent of impairment vary among the different cell types? What is the timing of onset for functional alterations? To answer these outstanding inquiries, we performed whole-cell patch clamp recordings on mouse brain slices of w
ePoster · Neuroscience