Topic: spontaneous excitatory transmission

Studying human brain development has remained difficult as appropriate models lack. Recently, induced pluripotent stem cells (iPSC)-derived 3D brain organoids have been developed. They recapitulate the key aspects of human brain development such as the cellular complexity and functional properties of specific regions. Yet, longitudinal functional studies are sparse. During neurodevelopment in vivo, GABAergic inhibitory interneurons from the ventral cortex migrate to populate the dorsal part of the cortex enriched in glutamatergic excitatory neurons (Zhu et al. Neuron, 1999; Le et al., JBC, 200