Spatial transcriptomics reveals common pathways in Alzheimer's disease and Down syndrome
Arshi Shahin, Emily Miyoshi, Samuel Morabito, Caden Henningfield, Begin Rahimzadeh, Sudeshna Das, Elizabeth Head, Kim Green, Vivek Swarup · FENS Forum 2024
Alzheimer's disease (AD) is characterized by significant molecular heterogeneity, influenced by a complex interplay of genetic and environmental factors. This study aims to dissect cell-type-specific and spatial transcriptomic alterations in AD, with a particular focus on a subgroup of Down Syndrome (DS) patients afflicted by AD (AD in DS). Our objective is to explore the overlaps and distinctions between sporadic AD (sAD) and AD in DS, thereby providing insights that may bridge the gap between animal models and human AD conditions. We employed spatial transcriptomics (ST) in conjunction with
ePoster · Neuroscience