Synapsin 2a tetramerisation selectively controls the nanoscale clustering of reserve synaptic vesicles at the hippocampal presynapse
Shanley Sanders, Rachel S. Gormal, Matis Feller, Pierre Parutto, Jürgen Reingruber, Tristan P. Wallis, Merja Joensuu, George J. Augustine, Ramon Martinez-Marmol, David Holcman, Frédéric A. Meunier · FENS Forum 2024
Neurotransmitter release relies on the regulated fusion of synaptic vesicles (SVs) that are tightly packed within the presynaptic bouton of neurons. The ability of SVs to dynamically recycle while remaining clustered at the presynapse is unknown but suggests anchoring mechanisms that regulate SV function. One potential anchor is a family of phosphoproteins that interact with presynaptic SVs, called synapsins. Synapsins tightly bind SVs and form biomolecular condensates via liquid-liquid phase separation which can potentially help trap SVs at the presynapse. An alternative model for synapsin’s
ePoster · Neuroscience