Sulfiredoxin 1 ameliorates oxidative stress in HT22 cells and ischemic damage in gerbils
In Koo Hwang, Kyu Ri Hahn, Hyun Jung Kwon, Dae Young Yoo, Dae Won Kim, Seung Myung Moon · FENS Forum 2024
In the present study, we validated the neuroprotective effects of sulfiredoxin 1 (SRXN1) protein against oxidative damage in HT22 cells and ischemic damage in gerbil hippocampus. To deliver SRXN1 protein into cells or hippocampus, PEP-1-SRXN1 fusion protein was synthesized and the efficient delivery was visualized in HT22 cells and gerbil hippocampus. In addition, the treatment of PEP-1-SRXN1 was delivered in HT22 cells with concentration- and incubation time-dependent manners. In addition, PEP-1-SRXN1 treatment significantly ameliorated formation of reactive oxygen species and cell death in H
ePoster · Neuroscience