Impaired and diminished long-range GABAergic neurons as the major perturbation in a microdeletion model of human neuropsychiatric disorders
Katarina Dragicevic, Andrea Asenjo-Martinez, Navneet A Vasistha, Konstantin Khodosevich · FENS Forum 2024
Neuropsychiatric disorders, such as schizophrenia, have a strong genetic basis and are linked to structural genomic changes such as copy number variations, including the 15q13.3 microdeletion. This study investigates the impact of the 15q13.3 microdeletion on neuronal maturation in the cerebral cortex, using a mouse model. We performed single-cell transcriptomics to analyse the transcriptomic changes in neuronal subtypes at different maturational stages. Compositional changes were validated with immunohistochemistry, while functional validation was conducted through calcium imaging and Patch-s
ePoster · Neuroscience