Topic: SST+ interneurons

Approximately 25% of all cortical neurons are inhibitory interneurons, with somatostatin-positive interneurons (SST+ interneurons) representing a distinct subtype expressing both somatostatin and GABA. These cells form synapses with pyramidal neurons and other interneurons, crucial for modulating cortical information processing and maintaining excitation/inhibition balance. Originating from the medial ganglionic eminence, SST+ interneurons follow a tangential pathway to the cortex, making them susceptible to gene mutations affecting neuronal migration. One such gene, Platelet-activating factor