Autocrine and paracrine action of somatostatin released by O-LM interneurons on the CA1 feedback circuit
Maria Laura Musella, Zois Syrgiannis, Matias Alvarez-Saavedra, Samuel I. Stupp, Dominique Debanne, Salvatore Incontro · FENS Forum 2024
Somatostatin (SST) is a neuropeptide which expression characterizes a subpopulation of GABAergic interneurons. SST exerts its physiological role through 5 G protein-coupled receptors. This neuropeptide is of great interest in the pathophysiological context as a deficit of SST is observed in many neurological diseases, such as epilepsy. In the hippocampus, the effects of SST on the principal cells are known. It inhibits excitatory synaptic transmission by decreasing glutamate release from pyramidal neurons and reduces their intrinsic excitability by facilitating currents carried by Kv7 channels
ePoster · Neuroscience