Topic: STARR-seq

Patterns of gene expression define the status of a cell in physiological as well as pathological conditions. The interplay of gene promoters and enhancers has been identified as a major mechanism to control specific expression patterns. Furthermore, combinations of enhancer elements with a preferable activity profile together with a small core promoter are starting to be used to drive transcription in gene delivery vectors.However, the identification of enhancers often relies on indirect measures, such as DNA conservation or epigenetic signatures. In addition, functional screens for enhancer a