KIBRA anchoring the action of PKMζ maintains the persistence of memory
Panayiotis Tsokas, Changchi Hsieh, Rafael E. Flores-Obando, Matteo Bernabo, Andrew Tcherepanov, A. Iván Hernández, Christian Thomas, Peter J. Bergold, James E. Cottrell, Joachim Kremerskothen, Harel Z. Shouval, Karim Nader, André Antonio Fenton, Todd Charlton Sacktor · FENS Forum 2024
How can short-lived molecules selectively maintain potentiation of synapses to sustain long-term potentiation (late-LTP) and long-term memory? One possibility, suggested by Francis Crick (Nature, 1984), is that continual interaction between synaptic molecules maintains the strengthening of activated synapses in the face of molecular turnover. Here, we tested the hypothesis that continual interaction between KIBRA, a postsynaptic scaffolding protein genetically linked to human memory performance, with the autonomously active, atypical PKC isoform PKMζ, maintains late-LTP and long-term memory. U
ePoster · Neuroscience