Topic: Statins

Statins represent a class of drugs commonly prescribed for lowering cholesterol levels, thereby reducing the risk of atherosclerotic cardiovascular disease. While accumulating evidence indicates an increased risk of peripheral neuropathy with prolonged statin use in humans, in vivo animal studies revealed an anti-nociceptive effect of these drugs without fully elucidating the underlying mechanisms. Transient receptor potential (TRP) ion channels represent a major class of receptors that are expressed in the peripheral nervous system and are involved in pain signaling. Among these channels, TRP