Topic: stimulus-reward association

The hippocampus and the medial prefrontal cortex (mPFC) participate in episodic and working memory, respectively. In trace conditioning, animals learn to associate a sensory stimulus (CS) and a reward (US) separated by a delay (trace period). Although the neural activity in both areas can be linked to memory representation formation, the neural mechanisms involved in learning the temporal association between CS and US are not known. In this work, we use auditory trace conditioning in head-fixed mice with simultaneous 128-channel silicon probe recordings from the hippocampal CA1 subfield and th