ePoster · Neuroscience
Compulsive-like seeking behavior correlates with AMPA receptor rectification in synapses of the subthalamic nucleus in a rat model of cocaine addiction
Monica Tapia Pacheco, Maya Williams, Lucie Vignal, Christelle Baunez, Jean-Marc Goaillard, Mickaël Degoulet · FENS Forum 2024
Compulsive drug seeking is a key behavioral trait when studying transition to cocaine addiction in rodent models. Understanding how neurophysiological changes operate in circuits of compulsion, and searching for molecular markers to distinguish addictive vs. non-addictive individuals may help us to understand the mechanisms underlying cocaine addiction. Cocaine-evoked synaptic plasticity has been shown to correlate with addictive-like behavior in certain brain regions of the mesolimbic dopamine system. In the subthalamic nucleus (STN), specific oscillatory frequencies are associated to compuls