An obesity-associated switch in vagal gut-brain communication modulates feeding behavior
Leonie Cabot, Juliet Erlenbeck-Dinkelmann, Diba Borgmann, Lara Kern, Thomas Wunderlich, Henning Fenselau · FENS Forum 2024
In obesity, disruption of gut-brain communication has been associated with overeating, body weight gain, and metabolism disorders. Vagal sensory neurons (VSN) relay nutrient-related signals from the gut to the brain, but how distinct, gut-innervating VSN subtypes are affected by obesity remains unclear. We employed an intersectional genetic approach to investigate obesity-induced functional changes in molecularly defined VSN subtypes that innervate the stomach and small intestine. We demonstrate that overexpression of the suppressor of cytokine signaling 3 (Socs3), a crucial regulator of lepti
ePoster · Neuroscience