Nanoscale reorganization of axo-axonic synapses at the axonal initial segment driven by network activity
Benjamin Compans, Vincenzo Mastrolia, Clara Lenherr, Juan Burrone · FENS Forum 2024
The nanoscale arrangement of chemical synapses is thought to be critical for establishing synapse strength but whether this arrangement is sensitive to changes in in vivo activity is not known. Pyramidal neurons in the cortex receive a multitude of excitatory and inhibitory inputs that determine the generation of the action potential (AP) at the axon initial segment (AIS). Chandelier cells (ChCs), a GABAergic interneuron subtype, targets the AIS of pyramidal neurons through axo-axonic synapses and is therefore thought to strongly modulate neuronal output. We used super-resolution microscopy (S
ePoster · Neuroscience