Ketogenic diet buffers brain gene expression and ethanol consumption induced by vicarious social defeat exposure in female mice
Marta M Rodriguez Arias, Laura Torres-rubio, Susana Mellado, Maria Pascual, Jose Miñarro · FENS Forum 2024
The ketogenic diet (KD) is known to reduce ethanol consumption in non-stress conditions (Blanco-Gandía et al. 2021). Therefore, our objective was to assess whether KD modifies stress-induced changes in gene expression and ethanol consumption in female mice. 64 female OF1 mice were categorized into four groups based on the administered diet (KD vs. Standard Diet, STD) and exposure to stress (Vicarious Social Defeat sessions, VSD, vs. Exploration sessions, EXP): STD-EXP (n=16), STD-VSD (n=16), KD-EXP (n=16), and KD-VSD (n=16). The KD-fed mice remained in ketosis from adolescence until the final
ePoster · Neuroscience