Neuromodulatory role of relaxin-3/RXFP3 signaling in stress- and anxiety-related circuits: Insights from the rat ventral dentate gyrus
Gabriela Stopka, Aleksandra Trenk, Anna Gugula, Kinga Przybylska, Aleksandra Nogaj, Emilia Goszczynska, Andrew L. Gundlach, Anna Blasiak · FENS Forum 2024
The dentate gyrus of the ventral hippocampus (vDG) is strongly implicated in the pathophysiology of anxiety disorders. vDG is heavily innervated by the nucleus incertus (NI), a dorsal pontine locus highly sensitive to neurogenic stress and the main source of the neuropeptide, relaxin-3 (RLN3) in the rat brain. RLN3 receptor (RXFP3) activation has been shown to modulate behaviours, including stress-related anxiety. However, the effect of RLN3/RXFP3 signaling on vDG neuronal activity has not been examined. Therefore, this study investigated the influence of RLN3 on rat vDG neuronal activity ex v
ePoster · Neuroscience