Long-term (intergenerational) effects of chronic stress on mouse behavior and its interaction with the circadian gene regulation in the hippocampus
Vincent Fischer, Miriam Kretschmer, Iryna Ivanova, Philipp Kohling, Pierre-Luc Germain, Katharina Gapp · FENS Forum 2024
Almost daily we face stressful situations and the body reacts with various coping mechanisms. Consequently, glucocorticoids are released, leading to immunosuppression and a changed metabolism. However, if the stress becomes chronic, the coping systems can be maladaptively altered. In addition, glucocorticoid levels follow a daily circadian rhythm with a peak in the morning just before the organism starts to become active. While it is known that chronic stress can lead to a disruption of the circadian rhythm, it is still not fully understood how the long-term effects after chronic stress and th
ePoster · Neuroscience