MolBoolean staining reveals high proportion of D2 receptors forming A2A-D2 heteromers in striatal neurons of MPTP-lesioned parkinsonian primates
Rafael Rivas-Santisteban, Alberto Jose-Rico, Ana Muñoz, Ana I Rodríguez-Pérez, Irene Reyes-Resina, Gemma Navarro, José Luis Labandeira-García, José Luis Lanciego, Rafael Franco · FENS Forum 2024
Parkinson's disease (PD) is a neurodegenerative disorder characterized by loss of dopaminergic neurons in the substantia nigra pars compacta, leading to striatal dopamine deficiency. The A2A and D2 receptors form heteromeric complexes in striatal neurons that play an important modulatory role in fine-tuning motor control.The aim of this study was to assess, for the first time, the proportion of individual A2AR, of individual D2R and of A2AR-D2R heteromers (A2A-D2Het) present in a primate 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine (MPTP) PD model, with and without showing dyskinesias. This h
ePoster · Neuroscience