Oligomeric alpha-synuclein causes early striatal synaptic dysfunction associated with non-motor symptoms
Alessandro Tozzi, Laura Bellingacci, Alfredo Megaro, Miriam Sciaccaluga, Antonella Cardinale, Jacopo Canonichesi, Maria De Carluccio, Roberta Mastrantonio, Maria Teresa Viscomi, Paolo Calabresi · FENS Forum 2024
In synucleinopathies, α-synuclein (α-syn) is thought to exist within a dynamic equilibrium, comprising both α-syn oligomers (OSyn) and more aggregated forms. OSyn has been associated to neurodegeneration, neurotoxicity, and proinflammatory responses, even at low concentrations and is thought to be involved in Parkinson’s disease (PD) pathogenesis.To date, it is not clear whether the neurotoxicity exerted by α-syn aggregates is due to the presence of scattered oligomeric species, anticipating the formation of proper fibrillary α-syn, or whether it is sustained by α-syn species that are already
ePoster · Neuroscience