Topic: striatal neuronal circuits

Schizophrenia, a complex neuropsychiatric condition impacting 0.5-1% of adults, manifests through positive, negative, and cognitive symptoms affecting emotions, thought processes, and perception. Onset typically occurs from late adolescence to early adulthood, with genetic and early-life environmental factors implicated in its strongly neurodevelopmental origin. The dopamine system plays a central role in schizophrenia's pathogenesis, with dopamine 2 receptor antagonists as the first line of treatment since the 1950s. Numerous studies highlight abnormal dopamine functions in schizophrenia pati