Topic: stroke injury

Ischemic stroke is a leading cause of global disability, yet the precise pathogenic mechanisms remain elusive, limiting the effectiveness of treatments. This issue is compounded by animal models that inadequately reflect critical patient characteristics, such as health status and age, and the predominant use of male subjects, despite stroke affecting all genders. Consequently, treatments validated in male-centric models may prove ineffective or even detrimental for females. To gain a comprehensive understanding of sex-specific mechanisms underlying stroke injury, protection, and repair, we are