Neuronal pERK expression in amygdala subregions reveals differential encoding of fear memory strength in a mouse model of PTSD
Fionnghuala James, Sanket Raut, Sayed Ahamed, Juan Canales, Vanni Caruso, Luke Johnson · FENS Forum 2024
Strong fear memories resistant to modification are a key hallmark of trauma disorders such as post-traumatic stress disorder (PTSD). However, the neural mechanisms behind the encoding of these memories, and how these may differ in terms of strength, remain poorly understood. In this study, C57BL/6 mice were divided into four treatment groups (strong fear memory, weak fear memory, unpaired strong control, unpaired weak control) and underwent an auditory fear memory reconsolidation paradigm over the course of three days. Brains were stained using immunocytochemistry (ICC) for pERK expression in
ePoster · Neuroscience