Topic: strychnine

Although traditionally thought to act primarily in the spinal cord, emerging evidence support important inhibitory functions by glycinergic transmission in the brain. In the ventral pallidum (VP), glycinergic afferents from the brainstem make synapses onto cholinergic interneurons to regulate arousal. Notably, VP is comprised of a heterogeneous population of GABAergic neurons, of which those that express somatostatin (SOM+) comprise a significant group and have been implicated in the control of sleep and wakefulness directly inhibiting cholinergic, glutamatergic and parvalbumin neurons. Here,