Topic: Stx3

Long-term potentiation (LTP) is thought to be a key plasticity mechanism underlying the formation and maintenance of hippocampal place codes. It is unclear, however, which properties of these neural codes are inherited from upstream processing and which are learned through plasticity. To disentangle these influences on place codes, we utilized a method for abolishing LTP specifically in hippocampal region CA1 of the adult mouse without affecting basal synaptic processing: conditional genetic deletion of a necessary component of the postsynaptic membrane fusion machinery, Syntaxin3 (Stx3). Surp