ePoster · Behavioral Neuroscience
Evaluation of novel object recognition test results of rats injected with intracerebroventricular streptozocin to develop Alzheimer's disease models
Berna Özen, Hasan Raci Yananlı · FENS Forum 2024
It is challenging to create chemical-induced models of Alzheimer’s disease without using genetically bred animals. Intracerebroventricular (ICV) streptozocin (STZ) administration at a sub-diabetogenic dose can serve as a viable model for cognitive impairment associated with Alzheimer's disease via a disruption of glucose and energy metabolism in the brain, accompanied by oxidative stress and a concurrent impact on cognitive function. The aim of this study is to evaluate the behavioral results of once or twice injections of the ICV STZ administration methods. ICV guide cannulas were placed unil