T-lymphocyte infiltration in the brain parenchyma is a hallmark of acute neuroinflammation following subarachnoid hemorrhage in mice
Edoardo Mazzone, Federico Moro, Silvia Monticelli, Marian Bataclan, Jens Geginat, Chiara Vasco, Tommaso Zoerle, Elisa R. Zanier · FENS Forum 2024
Subarachnoid hemorrhage (SAH) triggers neuroinflammation including the recruitment and activation of immune cells. T-cells in particular, have been shown to promote the evolution of secondary injury following ischemic stroke, however their role in SAH is still unclear.In this study we aimed to evaluate T-cells’ recruitment in the brain of SAH-injured mice to next investigate their specific role in injury progression.Adult C57BL/6J mice were subjected to SAH by blood injection in the prechiasmatic cistern or sham procedure and sacrificed at 3 or 7 days-post-injury (dpi). Sensorimotor deficits w
ePoster · Neuroscience