Topic: subicular neurons

The axon initial segment (AIS) is an axonal subdomain integral to neuronal excitability, yet its geometrical diversity within the hippocampus is poorly understood. This study provides a detailed examination of the variability of proximal cell morphology across murine hippocampal neurons, analyzing molecular and geometrical parameters such as AIS length and position, dendrite shape, soma, and apical dendrite size across dorsal-ventral, superficial-deep, and proximal-distal axes. We observed significant differences in AIS characteristics, with CA3 neurons displaying longer AIS and more distal or