Changes in hippocampal volume following intravenous ketamine administration in healthy individuals
Samantha Graf, Gregor Dörl, Christian Milz, Maximilian Kathofer, Peter Stöhrmann, Benjamin Eggerstorfer, Clemens Schmidt, David Gomola, Elisa Briem, Gabriel Schlosser, Rupert Lanzenberger, Julia Crone, Marie Spies, Benjamin Spurny-Dworak · FENS Forum 2024
Ketamine, a rapid acting antidepressant ( Zarate et al. 2006), induces acute hippocampal volumetric changes ( Höflich et al. 2021). Considering the observed link between major depressive disorder (MDD) and a lower hippocampal volume (MacQueen et al. 2011), investigating ketamine-induced neuroplastic changes in this region may contribute to understand treatment effects.In a placebo-controlled, single-blind, crossover study 36 healthy subjects (17males, 23.8±3.75 years) received either 0.5mg/kg racemic ketamine or placebo 4 hours before MRI scans. FreeSurfer7.1 was used for the hippocampal subfi
ePoster · Neuroscience